Beneficial and detrimental roles of NLRs in carcinogenesis

Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. One major source of IL-1β a...

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Bibliographic Details
Main Authors: Ann M Janowski, Ryan eKolb, Weizhou eZhang, Fayyaz S Sutterwala
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00370/full