A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring.

A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring.

Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes 19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters. However, whether individual isoforms or exon clusters have specific significance is unclear. Here, using phenotype-diversity c...

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Bibliographic Details
Main Authors: Haiyang Dong, Xi Yang, Lili Wu, Shixin Zhang, Jian Zhang, Pengjuan Guo, Yiwen Du, Changkun Pan, Ying Fu, Lei Li, Jilong Shi, Yanda Zhu, Hongru Ma, Lina Bian, Bingbing Xu, Guo Li, Feng Shi, Jianhua Huang, Haihuai He, Yongfeng Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002197

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https://doi.org/10.1371/journal.pbio.3002197

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