Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues.

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues.

Cytosolic 5'-nucleotidase II (cN-II) regulates the intracellular nucleotide pools within the cell by catalyzing the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. Beside this physiological function, high level of cN-II expression is correlated with abnormal patient outc...

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Bibliographic Details
Main Authors: Franck Gallier, Perrine Lallemand, Maïa Meurillon, Lars P Jordheim, Charles Dumontet, Christian Périgaud, Corinne Lionne, Suzanne Peyrottes, Laurent Chaloin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3234209?pdf=render

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http://europepmc.org/articles/PMC3234209?pdf=render

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