Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene

The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor cells during commitment of primitive mesoderm to the cardiomyogenic lineage. Up-regulation of Nkx2.5 expression by desmin suggests that desmin may contribute to cardiogenic...

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Bibliographic Details
Main Authors: Christiane Fuchs, Sonja Gawlas, Philipp Heher, Sofia Nikouli, Hannah Paar, Mario Ivankovic, Martina Schultheis, Julia Klammer, Teresa Gottschamel, Yassemi Capetanaki, Georg Weitzer
Format: Article
Language:English
Published: The Company of Biologists 2016-02-01
Series:Biology Open
Subjects:
Cardiac progenitor cells
Desmin
Nkx2.5
Nuclear localization
Transcriptional regulation
Intermediate filament protein
Online Access:http://bio.biologists.org/content/5/2/140

Internet

http://bio.biologists.org/content/5/2/140

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