Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes

Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes

Background: The rapid delayed rectifier K+ current (IKr), carried by the hERG protein, is one of the main repolarising currents in the human heart and a reduction of this current increases the risk of ventricular fibrillation. α1-adrenoceptors (α1-AR) activation reduces IKr but, despite the clear re...

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Bibliographic Details
Main Authors: Janire Urrutia, Aintzane Alday, Mónica Gallego, L. Layse Malagueta-Vieira, Ivan Arael Aréchiga-Figueroa, Oscar Casis, José Antonio Sánchez-Chapula
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Phosphatidylinositol 4,5-bisphosphate
Src
PKA
hERG
PKC
IKr
Online Access:http://www.karger.com/Article/FullText/453180

Internet

http://www.karger.com/Article/FullText/453180

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