Downregulation of <i>ORP3</i> Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer
Genome instability is an essential hallmark in tumor development, including colorectal cancer. We have recently identified the oxysterol binding protein-related protein 3 (ORP3), also known as oxysterol binding protein-like 3 (OSBPL3), as a novel ploidy-control gene, whose knock-out leads to aneuplo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/16/5894 |
| Summary: | Genome instability is an essential hallmark in tumor development, including colorectal cancer. We have recently identified the oxysterol binding protein-related protein 3 (ORP3), also known as oxysterol binding protein-like 3 (OSBPL3), as a novel ploidy-control gene, whose knock-out leads to aneuploidy induction and promotes tumor formation, indicating that ORP3 is a bona fide tumor suppressor protein. Here we analyzed expression of <i>ORP3</i> in a cohort (<i>n</i> = 206) of colon cancer patients in relation to patient survival. We show that low <i>ORP3</i> mRNA levels correlate with reduced survival of patients with advanced nodal metastasis (N2). While patient survival does not associate with grading when the whole cohort is evaluated, importantly, low <i>ORP3</i> mRNA levels associate with worse survival of female patients with grade 3 colon cancer. Similarly, low <i>ORP3</i> mRNA levels associate with worse survival of grade 3 colon cancer patients 70 years of age and younger while low <i>ORP3</i> mRNA levels seem to be beneficial for colon cancer patients with a T2 tumor size. Together, the data show that <i>ORP3</i> expression is downregulated during colon cancer progression, which correlates with reduced patient survival. Thus, <i>ORP3</i> mRNA levels may be a prognostic marker for better stratification of colon cancer patients. |
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| ISSN: | 1661-6596 1422-0067 |