Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured illumination microscopy, compound...

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Bibliographic Details
Main Authors: Huajie Li, Zhenjie Yu, Haoyi Sun, Bo Liu, Xin Wang, Zhe Shao, Meiling Wang, Weilin Xie, Xingang Yao, Qingqiang Yao, Ying Zhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
spirooxindole
aza-ortho-quinone methides
mitochondria
morphology
annulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.821518/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.821518/full

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