Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis (ALS) involves injury to motor neurons (MNs), activation of glial cells and immune unbalance. However, neuroinflammation, besides its detrimental effects, also plays beneficial roles in ALS pathophysiology. There...

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Bibliographic Details
Main Authors: Ana Rita Vaz, Sara Pinto, Catarina Ezequiel, Carolina Cunha, Luís A. Carvalho, Rui Moreira, Dora Brites
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
mutant SOD1G93A
microglia reactivity
inflammatory-associated microRNAs
glycoursodeoxycholic acid
vinyl sulfone
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00109/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00109/full

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