Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina

Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina

Polyamine oxidation plays a major role in neurodegenerative diseases. Previous studies from our laboratory demonstrated that spermine oxidase (SMOX, a member of the polyamine oxidase family) inhibition using MDL 72527 reduced neurodegeneration in models of retinal excitotoxicity and diabetic retinop...

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Bibliographic Details
Main Authors: Moaddey Alfarhan, Fang Liu, Shengshuai Shan, Prahalathan Pichavaram, Payaningal R. Somanath, S. Priya Narayanan
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
neuroinflammation
polyamine oxidation
spermine oxidase
acrolein
microglia
oxidative damage
Online Access:https://www.mdpi.com/1422-0067/23/4/2133

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https://www.mdpi.com/1422-0067/23/4/2133

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