APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

APOBEC’s are a family of cytidine deaminases that induce mutations in viruses to inhibit their replication and maintain cell integrity. Here, Manjunath et al show that APOBEC3B also inhibits viral replication by stimulating the innate immune sensor protein kinase R causing translational shutdown and...

Full description

Bibliographic Details
Main Authors: Lavanya Manjunath, Sunwoo Oh, Pedro Ortega, Alexis Bouin, Elodie Bournique, Ambrocio Sanchez, Pia Møller Martensen, Ashley A. Auerbach, Jordan T. Becker, Marcus Seldin, Reuben S. Harris, Bert L. Semler, Rémi Buisson
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36445-9

Internet

https://doi.org/10.1038/s41467-023-36445-9

Similar Items