Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Abstract Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural stability of the Toll‐like receptor‐4 (TLR4)‐interacting SPA4 peptide, its effect on Pseudomonas aeruginosa lipopolysaccharide (LPS)‐d...

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Bibliographic Details
Main Authors: Asif Alam Chowdhury, Nachiket M. Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Physiological Reports
Subjects:
epithelial barrier
lipopolysaccharide
lung injury
Online Access:https://doi.org/10.14814/phy2.15353

Internet

https://doi.org/10.14814/phy2.15353

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