FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways

FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways

Abstract Background Mutations in the receptor tyrosine kinase gene fibroblast growth factor receptor 2 (FGFR2) occur at a high frequency in endometrial cancer (EC) and have been linked to advanced and recurrent disease. However, little is known about how these mutations drive carcinogenesis. Methods...

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Bibliographic Details
Main Authors: Garima Dixit, Jesus Gonzalez‐Bosquet, Joseph Skurski, Eric J. Devor, Erin B. Dickerson, Warren B. Nothnick, Priya D. Issuree, Kimberly K. Leslie, Thorsten Maretzky
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Clinical and Translational Medicine
Subjects:
a disintegrin and metalloprotease 10
a disintegrin and metalloprotease 17
endometrial cancer
epidermal growth factor receptor
fibroblast growth factor receptor 2
Notch
Online Access:https://doi.org/10.1002/ctm2.1223

Internet

https://doi.org/10.1002/ctm2.1223

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