Diagnostic Potential of Plasma IgA1 O-Glycans in Discriminating IgA Nephropathy From Other Glomerular Diseases and Healthy Participants

Diagnostic Potential of Plasma IgA1 O-Glycans in Discriminating IgA Nephropathy From Other Glomerular Diseases and Healthy Participants

Background: Aberrant O-glycosylation of IgA1 plays an important role in IgA nephropathy pathogenesis. Previous proteomic studies analyzed O-glycans of the circulating IgA1 hinge region and found that the N-acetylgalactosamine (GalNAc) and galactose numbers in the hinge region of IgA1 of patients wit...

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Bibliographic Details
Main Authors: Shuyu Zhang, Haidan Sun, Zejian Zhang, Menglin Li, Zhengguang Guo, Wenling Ye, Guangyan Cai, Wei Sun, Mingxi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
iga nephropathy
O-glycosylation
IgA1 hinge region
glycoproteomics
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.871615/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.871615/full

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