Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.

Bibliographic Details
Main Authors: Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J. Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu, Yi-Ping Li
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00726-x

Internet

https://doi.org/10.1038/s41467-017-00726-x

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