Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00726-x |
| _version_ | 1819129478086918144 |
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| author | Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li |
| author_facet | Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li |
| author_sort | Guohua Zhang |
| collection | DOAJ |
| description | Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia. |
| first_indexed | 2024-12-22T08:44:21Z |
| format | Article |
| id | doaj.art-e1eba5b33bfe496a995e5d12f008fd11 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:44:21Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e1eba5b33bfe496a995e5d12f008fd112022-12-21T18:32:09ZengNature PortfolioNature Communications2041-17232017-09-018111610.1038/s41467-017-00726-xTumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90Guohua Zhang0Zhelong Liu1Hui Ding2Yong Zhou3Hoang Anh Doan4Ka Wai Thomas Sin5Zhiren J. Zhu6Rene Flores7Yefei Wen8Xing Gong9Qingyun Liu10Yi-Ping Li11Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Academic and Research Affairs, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)The Brown Foundation Institution of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth)The Brown Foundation Institution of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth)Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (UTHealth)Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.https://doi.org/10.1038/s41467-017-00726-x |
| spellingShingle | Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 Nature Communications |
| title | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 |
| title_full | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 |
| title_fullStr | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 |
| title_full_unstemmed | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 |
| title_short | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90 |
| title_sort | tumor induces muscle wasting in mice through releasing extracellular hsp70 and hsp90 |
| url | https://doi.org/10.1038/s41467-017-00726-x |
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