The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells

Neuroblastoma (NB) is a heterogeneous cancer of the sympathetic nervous system, which accounts for 7–10% of paediatric malignancies worldwide. Due to the lack of targetable molecular aberrations in NB, most treatment options remain relatively nonspecific. Here, we investigated the therapeutic potent...

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Bibliographic Details
Main Authors: Elliott M. Thompson, Vruti Patel, Vinothini Rajeeve, Pedro R Cutillas, Andrew W. Stoker
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:FEBS Open Bio
Subjects:
chemical inhibition
CRISPR‐Cas9
dual‐specificity phosphatase
MAPK signalling
neuroblastoma
phosphoproteomics
Online Access:https://doi.org/10.1002/2211-5463.13418

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