Antiretroviral Imprints and Genomic Plasticity of HIV-1 pol in Non-clade B: Implications for Treatment

Antiretroviral Imprints and Genomic Plasticity of HIV-1 pol in Non-clade B: Implications for Treatment

Combinational antiretroviral therapy (cART) is the most effective tool to prevent and control HIV-1 infection without an effective vaccine. However, HIV-1 drug resistance mutations (DRMs) and naturally occurring polymorphisms (NOPs) can abrogate cART efficacy. Here, we aimed to characterize the HIV-...

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Bibliographic Details
Main Authors: Jude S. Bimela, Aubin J. Nanfack, Pengpeng Yang, Shaoxing Dai, Xiang-Peng Kong, Judith N. Torimiro, Ralf Duerr
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 polymerase (pol)
non-clade B drug resistance mutations (DRMs)
naturally occurring polymorphisms (NOPs)
CRF02_AG
antiretroviral imprints
genomic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.812391/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.812391/full

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