Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears

Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears

Abstract Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not so severe in Achilles tendon tears (ATT). The knowledge of why fatty infiltration i...

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Bibliographic Details
Main Authors: Xingzuan Lin, Peng Wang, Wei Wang, Hao Zhou, Siyuan Zhu, Shujing Feng, Yuzhou Chen, Han Zhou, Qichao Wang, Hanlong Xin, Xiexiang Shao, Jianhua Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01618-4

Internet

https://doi.org/10.1038/s41420-023-01618-4

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