Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears
Abstract Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not so severe in Achilles tendon tears (ATT). The knowledge of why fatty infiltration i...
Main Authors: | Xingzuan Lin, Peng Wang, Wei Wang, Hao Zhou, Siyuan Zhu, Shujing Feng, Yuzhou Chen, Han Zhou, Qichao Wang, Hanlong Xin, Xiexiang Shao, Jianhua Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-08-01
|
Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-023-01618-4 |
Similar Items
-
Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes
by: Mengyao Liu, et al.
Published: (2023-11-01) -
A 3D adipogenesis platform to study the fate of fibro/adipogenic progenitors in muscular dystrophies
by: Alessio Reggio, et al.
Published: (2023-06-01) -
Characterization of the Skeletal Muscle Secretome Reveals a Role for Extracellular Vesicles and IL1α/IL1β in Restricting Fibro/Adipogenic Progenitor Adipogenesis
by: Simone Vumbaca, et al.
Published: (2021-08-01) -
Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression
by: Dong Uk Im, et al.
Published: (2019-11-01) -
GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer
by: Richard L. Watson, et al.
Published: (2010-05-01)