Quantitation of the A<sub>2A</sub> Adenosine Receptor Density in the Striatum of Mice and Pigs with [<sup>18</sup>F]FLUDA by Positron Emission Tomography

Quantitation of the A<sub>2A</sub> Adenosine Receptor Density in the Striatum of Mice and Pigs with [<sup>18</sup>F]FLUDA by Positron Emission Tomography

The cerebral expression of the A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR) is altered in neurodegenerative diseases such as Parkinson’s (PD) and Huntington’s (HD) diseases, making these receptors an attractive diagnostic and therapeutic target. We aimed to further in...

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Bibliographic Details
Main Authors: Daniel Gündel, Magali Toussaint, Thu Hang Lai, Winnie Deuther-Conrad, Paul Cumming, Susann Schröder, Rodrigo Teodoro, Rareş-Petru Moldovan, Francisco Pan-Montojo, Bernhard Sattler, Klaus Kopka, Osama Sabri, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
7–(3–(4–(2–[<sup>18</sup>F]fluoroethoxy–1,1,2,2–d4)phenyl)propyl)–2–(furan–2–yl)–7H–pyrazolo[4,3–e][1,2,4]triazolo–[1,5–c]pyrimidin–5–amine ([<sup>18</sup>F]FLUDA)
A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR)
Parkinson’s disease (PD)
Huntington’s disease (HD)
kinetic analysis
preclinical positron emission tomography (PET)
Online Access:https://www.mdpi.com/1424-8247/15/5/516

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https://www.mdpi.com/1424-8247/15/5/516

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