Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays

Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays

Abstract Background The carcinogenic potential of dimethylaniline (DMA) isomers in rodents and humans has been previously reported, and there is sufficient evidence for the carcinogenicity of 2,6-DMA in experimental animals. The target organ of carcinogenesis of 2,6-DMA is the nasal cavity. In the c...

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Bibliographic Details
Main Authors: Arihiro Kohara, Mariko Matsumoto, Akihiko Hirose, Makoto Hayashi, Masamitsu Honma, Takayoshi Suzuki
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Genes and Environment
Subjects:
Dimethylaniline
Comet assay
Transgenic mutation assay
Micronucleus assay
Mouse
Mutation spectrum
Online Access:http://link.springer.com/article/10.1186/s41021-018-0106-3

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http://link.springer.com/article/10.1186/s41021-018-0106-3

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