Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium

Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium

<p>Abstract</p> <p>Background</p> <p>Spontaneous cessation of growth is a frequent finding in uterine fibroids. Increasing evidence suggests an important role of cellular senescence in this growth control. Deciphering the underlying mechanisms of growth control that can...

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Bibliographic Details
Main Authors: Markowski Dominique N, Helmke Burkhard M, Radtke Arlo, Froeb Jennifer, Belge Gazanfer, Bartnitzke Sabine, Wosniok Werner, Czybulka-Jachertz Iris, Deichert Ulrich, Bullerdiek Jörn
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Women's Health
Subjects:
fibroids
p14<sup>Arf</sup>
senescence
apoptosis
MDM2 antagonists
Online Access:http://www.biomedcentral.com/1472-6874/12/2

Internet

http://www.biomedcentral.com/1472-6874/12/2

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