Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

Myeloid-derived suppressor cells (MDSC) have been identified in the peripheral blood and granulomas of patients with active TB disease, but their phenotype-, function-, and immunosuppressive mechanism- spectrum remains unclear. Importantly, the frequency and signaling pathways of MDSC at the site of...

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Bibliographic Details
Main Authors: Leigh Ann Kotze, Gian van der Spuy, Bryan Leonard, Adam Penn-Nicholson, Munyaradzi Musvosvi, Shirley McAnda, Stephanus T. Malherbe, Mzwandile Erasmus, Thomas Scriba, Coenraad F. N. Koegelenberg, Brian W. Allwood, Gerhard Walzl, Nelita du Plessis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
myeloid derived suppressor cells
alveolar macrophages
monocytes
tuberculosis
lung disease
bronchoalveolar lavage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.839747/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.839747/full

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