Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X

Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X

Abstract Background Endothelial injury caused by Type 2 diabetes mellitus (T2DM) is considered as a mainstay in the pathophysiology of diabetic vascular complications (DVCs). However, the molecular mechanism of T2DM-induced endothelial injury remains largely unknown. Here, we found that endothelial...

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Bibliographic Details
Main Authors: Shilong You, Jiaqi Xu, Zeyu Yin, Boquan Wu, Pengbo Wang, Mingjun Hao, Cheng Cheng, Mengke Liu, Yuanhui Zhao, Pengyu Jia, Hongkun Jiang, Da Li, Liu Cao, Xingang Zhang, Ying Zhang, Yingxian Sun, Naijin Zhang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cardiovascular Diabetology
Subjects:
Type 2 diabetes mellitus
Diabetic vascular complications
Endothelial injury
WWP2
DDX3X
Ubiquitination
Online Access:https://doi.org/10.1186/s12933-023-01818-3

Internet

https://doi.org/10.1186/s12933-023-01818-3

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