Eukaryotic Initiation Factor 5A2 localizes to actively translating ribosomes to promote cancer cell protrusions and invasive capacity

Eukaryotic Initiation Factor 5A2 localizes to actively translating ribosomes to promote cancer cell protrusions and invasive capacity

Abstract Background Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor, is post-translationally activated by the polyamine spermidine. Two human genes encode eIF-5A, being eIF5-A1 constitutively expressed whereas eIF5-A2 is frequently found overexpressed in human tumours. The...

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Bibliographic Details
Main Authors: Arantxa Martínez-Férriz, Carolina Gandía, José Miguel Pardo-Sánchez, Alihamze Fathinajafabadi, Alejandro Ferrando, Rosa Farràs
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
Eukaryotic translation initiation factor 5A2
TGFB1 signaling
Translating ribosomes
Cytoskeleton organization
Cell migration
Lung adenocarcinoma
Online Access:https://doi.org/10.1186/s12964-023-01076-6

Internet

https://doi.org/10.1186/s12964-023-01076-6

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