The Relationship of APOE ε4, Race, and Sex on the Age of Onset and Risk of Dementia

The Relationship of APOE ε4, Race, and Sex on the Age of Onset and Risk of Dementia

Objective: To investigate whether APOE ε4 genotype—an established risk factor for dementia—is associated with earlier age at diagnosis in addition to increased risk overall and in secondary analysis by race and sex.Methods: We followed up 13,782 dementia-free individuals (n = 10,137 White, n = 3,645...

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Main Authors: Danielle S. Powell, Pei-Lun Kuo, Riaz Qureshi, Sally B. Coburn, David S. Knopman, Priya Palta, Rebecca Gottesman, Michael Griswold, Marilyn Albert, Jennifer A. Deal, Alden L. Gross
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neurology
Subjects:
apolipoprotein ε allele
dementia
genetics
race
sex
cognitive aging
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.735036/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.735036/full

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