Hedgehog Signaling Regulates Taste Organs and Oral Sensation: Distinctive Roles in the Epithelium, Stroma, and Innervation

Hedgehog Signaling Regulates Taste Organs and Oral Sensation: Distinctive Roles in the Epithelium, Stroma, and Innervation

The Hedgehog (Hh) pathway has regulatory roles in maintaining and restoring lingual taste organs, the papillae and taste buds, and taste sensation. Taste buds and taste nerve responses are eliminated if Hh signaling is genetically suppressed or pharmacologically inhibited, but regeneration can occur...

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Bibliographic Details
Main Authors: Charlotte M. Mistretta, Archana Kumari
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
chorda tympani nerve
glossopharyngeal nerve
fungiform papilla
circumvallate papilla
geniculate ganglion
trigeminal ganglion
basal lamina
taste bud
sonidegib
hedgehog pathway inhibition
Online Access:http://www.mdpi.com/1422-0067/20/6/1341

Internet

http://www.mdpi.com/1422-0067/20/6/1341

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