Stem cells repurpose proliferation to contain a breach in their niche barrier

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically...

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Bibliographic Details
Main Authors: Kenneth Lay, Shaopeng Yuan, Shiri Gur-Cohen, Yuxuan Miao, Tianxiao Han, Shruti Naik, H Amalia Pasolli, Samantha B Larsen, Elaine Fuchs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/41661