Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors

Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors

Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore, inhibition of HDACs has become an interesting approach for the treatment of several diseases, including cancer, hematology, neurodegenerative...

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Bibliographic Details
Main Authors: Beatriz Silva Urias, Aline Renata Pavan, Gabriela Ribeiro Albuquerque, Igor Muccilo Prokopczyk, Tânia Mara Ferreira Alves, Thais Regina Ferreira de Melo, Geraldo Rodrigues Sartori, João Hermínio Martins da Silva, Chung Man Chin, Jean Leandro Dos Santos
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
histone deacetylase
resveratrol
enzymatic inhibition
gene regulation
new drugs
Online Access:https://www.mdpi.com/1424-8247/15/10/1260

Internet

https://www.mdpi.com/1424-8247/15/10/1260

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