Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
Introduction To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. Methods The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. Results The area of spleen fibrosis in the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-08-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Expression-of-CXCL12-CXCR4-CXCR7-chemokines-in-splenic-fibrosis-of-cirrhotic-spleen,170910,0,2.html |
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| author | Yunfu Lv Yejuan Li XiaoYu Han Ning Liu Min Zeng |
| author_facet | Yunfu Lv Yejuan Li XiaoYu Han Ning Liu Min Zeng |
| author_sort | Yunfu Lv |
| collection | DOAJ |
| description | Introduction
To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7.
Methods
The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR.
Results
The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01).
Conclusions
CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism. |
| first_indexed | 2024-03-09T10:48:51Z |
| format | Article |
| id | doaj.art-e21bf7b22c454144ba29bacc598a20e8 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:48:51Z |
| publishDate | 2023-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-e21bf7b22c454144ba29bacc598a20e82023-12-01T09:49:08ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512023-08-011951569157510.5114/aoms/170910170910Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significanceYunfu Lv0https://orcid.org/0000-0003-0451-399XYejuan Li1XiaoYu Han2Ning Liu3Min Zeng4https://orcid.org/0000-0001-6472-1980Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People’s Hospital), Haikou, ChinaReproductive Medicine Center of Hainan Women and Children’s Medical Center, Haikou, ChinaDepartment of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People’s Hospital), Haikou, ChinaDepartment of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People’s Hospital), Haikou, ChinaDepartment of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People’s Hospital), Haikou, ChinaIntroduction To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. Methods The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. Results The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). Conclusions CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.https://www.archivesofmedicalscience.com/Expression-of-CXCL12-CXCR4-CXCR7-chemokines-in-splenic-fibrosis-of-cirrhotic-spleen,170910,0,2.htmlliver cirrhosis with hypersplenismanimal experimentspleen fibrosischemotactic axis cxcl12-cxcr4/cxcr7therapeutic significance |
| spellingShingle | Yunfu Lv Yejuan Li XiaoYu Han Ning Liu Min Zeng Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance Archives of Medical Science liver cirrhosis with hypersplenism animal experiment spleen fibrosis chemotactic axis cxcl12-cxcr4/cxcr7 therapeutic significance |
| title | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| title_full | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| title_fullStr | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| title_full_unstemmed | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| title_short | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| title_sort | expression of cxcl12 cxcr4 cxcr7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
| topic | liver cirrhosis with hypersplenism animal experiment spleen fibrosis chemotactic axis cxcl12-cxcr4/cxcr7 therapeutic significance |
| url | https://www.archivesofmedicalscience.com/Expression-of-CXCL12-CXCR4-CXCR7-chemokines-in-splenic-fibrosis-of-cirrhotic-spleen,170910,0,2.html |
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