Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells

Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells

Background: Although cyclic AMP-response element binding protein-binding protein (CBP)/β-catenin signaling is known to promote proliferation and fibrosis in various organ systems, its role in the activation of pancreatic stellate cells (PSCs), the key effector cells of desmoplasia in pancreatic canc...

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Bibliographic Details
Main Authors: Mingtian Che, Soo-Mi Kweon, Jia-Ling Teo, Yate-Ching Yuan, Laleh G. Melstrom, Richard T. Waldron, Aurelia Lugea, Raul A. Urrutia, Stephen J. Pandol, Keane K. Y. Lai
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
pancreatic cancer
pancreatic stellate cells
Wnt signaling
CBP
p300
pancreatitis
Online Access:https://www.mdpi.com/2072-6694/12/6/1476

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https://www.mdpi.com/2072-6694/12/6/1476

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