Transcriptomic Analysis of the Acute Skeletal Muscle Effects after Intramuscular DNA Electroporation Reveals Inflammatory Signaling

Transcriptomic Analysis of the Acute Skeletal Muscle Effects after Intramuscular DNA Electroporation Reveals Inflammatory Signaling

Skeletal muscle is a promising tissue for therapeutic gene delivery because it is highly vascularized, accessible, and capable of synthesizing protein for therapies or vaccines. The application of electric pulses (electroporation) enhances plasmid DNA delivery and expression by increasing membrane p...

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Bibliographic Details
Main Authors: Amanda Sales Conniff, Jared Tur, Kristopher Kohena, Min Zhang, Justin Gibbons, Loree C. Heller
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Vaccines
Subjects:
skeletal muscle
plasmid electroporation
RNA sequencing
signaling pathways
Online Access:https://www.mdpi.com/2076-393X/10/12/2037

Internet

https://www.mdpi.com/2076-393X/10/12/2037

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