Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha

Abstract Inflammation plays an important role in the pathogenesis of intervertebral disc (IVD) degeneration. The proinflammatory cytokine tumor necrosis factor alpha (TNF‐α) has shown markedly higher expression in degenerated human disc tissue compared with healthy controls. Anti‐inflammatory treatm...

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Bibliographic Details
Main Authors: Jie Du, Judith‐J. Pfannkuche, Gernot Lang, Sonja Häckel, Laura B. Creemers, Mauro Alini, Sibylle Grad, Zhen Li
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:JOR Spine
Subjects:
3R
cytokines
inflammation
intervertebral disc
regeneration
spine
Online Access:https://doi.org/10.1002/jsp2.1104

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