Drug efflux and lipid A modification by 4-L-aminoarabinose are key mechanisms of polymyxin B resistance in the sepsis pathogen Enterobacter bugandensis

Drug efflux and lipid A modification by 4-L-aminoarabinose are key mechanisms of polymyxin B resistance in the sepsis pathogen Enterobacter bugandensis

ABSTRACT: Objectives: A concern with the ESKAPE pathogen, Enterobacter bugandensis, and other species of the Enterobacter cloacae complex, is the frequent appearance of multidrug resistance against last-resort antibiotics, such as polymyxins. Methods: Here, we investigated the responses to polymyxi...

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Bibliographic Details
Main Authors: Inmaculada García-Romero, Mugdha Srivastava, Julia Monjarás-Feria, Samuel O. Korankye, Lewis MacDonald, Nichollas E. Scott, Miguel A. Valvano
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Intrinsic antibiotic resistance
Outer membrane permeability
Cationic antimicrobial peptides
Enterobacter cloacae complex
Neonatal sepsis
KexD
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524000626

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http://www.sciencedirect.com/science/article/pii/S2213716524000626

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