WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

During normal cerebellar development, the remarkable expansion of granule cell progenitors (GCPs) generates a population of granule neurons that outnumbers the total neuronal population of the cerebral cortex, and provides a model for identifying signaling pathways that may be defective in medullobl...

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Bibliographic Details
Main Authors: Sandrine L Anne, Eve-Ellen Govek, Olivier Ayrault, Jee Hae Kim, Xiaodong Zhu, David A Murphy, Linda Van Aelst, Martine F Roussel, Mary E Hatten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3841149?pdf=render

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http://europepmc.org/articles/PMC3841149?pdf=render

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