Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis

Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis

Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on the activation of NLRP3 inflammasome and the pr...

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Bibliographic Details
Main Authors: Taha Yazal, Po-Yen Lee, Pin-Rong Chen, I-Chen Chen, Po-Len Liu, Yuan-Ru Chen, Tzu-Chieh Lin, Yi-Ting Chen, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Jung Lo, Hsin-En Wu, Shu-Chi Wang, Chia-Yang Li
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sophora flavescens aiton
Kurarinone
Anti-inflammation
NLRP3 inflammasome
NF-κB
Sepsis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223014178

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http://www.sciencedirect.com/science/article/pii/S0753332223014178

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