Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells

Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells

Bis-(3-bromo-4-hydroxy)benzylidene cyclic compounds have been reported by us as epigenetic multiple ligands, but different substitutions at the two wings provided analogues with selective inhibition. Since the 1-benzyl-3,5-bis((<i>E</i>)-3-bromobenzylidene)piperidin-4-one <b>3</...

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Bibliographic Details
Main Authors: Rossella Fioravanti, Stefano Tomassi, Elisabetta Di Bello, Annalisa Romanelli, Andrea Maria Plateroti, Rosaria Benedetti, Mariarosaria Conte, Ettore Novellino, Lucia Altucci, Sergio Valente, Antonello Mai
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
epigenetics
histone acetylation
histone methylation
drug discovery
multi-target agents
Online Access:https://www.mdpi.com/1420-3049/25/14/3122

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https://www.mdpi.com/1420-3049/25/14/3122

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