Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals. Cultured bloodstream-form trypanosomes, which are...

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Bibliographic Details
Main Authors: Zandile Nare, Tessa Moses, Karl Burgess, Achim Schnaufer, Malcolm D. Walkinshaw, Paul A. M. Michels
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma
phosphofructokinase
mode of inhibition
metabolomics
glycolytic metabolites
ATP production
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1129791/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1129791/full

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