Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

Abstract Introduction Regulatory T cells (Tregs) play an important role in inflammatory bowel diseases (IBDs) through modulating intestinal inflammation. However, the factors affecting Treg function and plasticity during IBD progression are not thoroughly disclosed. The current study aims to reveal...

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Bibliographic Details
Main Authors: Liuqing Ge, Min Xu, Meifang Huang, Shaoping Liu, Zhidai Zhou, Ziqin Xia, Qiu Zhao, Feng Zhou
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Immunity, Inflammation and Disease
Subjects:
inflammatory bowel disease
regulatory T cells
signal transducer and activator of transcription 3
Sirtuin2
T helper 17 cells
Online Access:https://doi.org/10.1002/iid3.1160

Internet

https://doi.org/10.1002/iid3.1160

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