Usnic Acid Potassium Salt: Evaluation of the Acute Toxicity and Antinociceptive Effect in Murine Model

Usnic Acid Potassium Salt: Evaluation of the Acute Toxicity and Antinociceptive Effect in Murine Model

To obtain usnic acid potassium salt (PS-UA), the usnic acid (UA) was extracted and purified from the lichen <i>Cladonia substellata</i>, and modified to produce PS-UA. The structure was determined by <sup>1</sup>H-NMR, IR and elemental analysis, ratified through computational...

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Main Authors: Hallysson Douglas A. Araújo, José G. Silva Júnior, João R. Saturnino Oliveira, Maria Helena M. L. Ribeiro, Mônica C. Barroso Martins, Marcos A. Cavalcanti Bezerra, André Lima Aires, Mônica C. P. Azevedo Albuquerque, Mário R. Melo-Júnior, Nicodemos T. Pontes Filho, Eugênia C. Pereira, Diego J. Raposo Silva, Janaína V. dos Anjos, Emerson Peter S. Falcão, Nicácio H. Silva, Vera L. Menezes Lima
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
lichen
<i>Cladonia substellata</i>
usnic acid derivatives
antinociceptive activity (phase I and II)
toxicological survey
soluble drug
histopathology
Online Access:https://www.mdpi.com/1420-3049/24/11/2042

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https://www.mdpi.com/1420-3049/24/11/2042

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