The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

Oxidative stress has been implicated in the etiology and pathobiology of various neurodegenerative diseases. At baseline, the cells of the nervous system have the capability to regulate the genes for antioxidant defenses by engaging nuclear factor erythroid 2 (NFE2/NRF)-dependent transcriptional mec...

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Bibliographic Details
Main Authors: Stephanie M. Boas, Kathlene L. Joyce, Rita M. Cowell
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
transcription
antioxidant defense
central nervous system
astrocytes
KEAP1
Online Access:https://www.mdpi.com/2076-3921/11/1/8

Internet

https://www.mdpi.com/2076-3921/11/1/8

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