An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint

An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint

In response to chromatin bridges, the chromosomal passenger complex (CPC) delays completion of cytokinesis (abscission) to prevent chromosome breakage. Here, we discuss recent findings from our lab showing that an ATM-CHK2-INCENP pathway imposes the abscission checkpoint in human cells by regulating...

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Bibliographic Details
Main Authors: Eleni Petsalaki, George Zachos
Format: Article
Language:English
Published: Taylor & Francis Group 2021-03-01
Series:Molecular & Cellular Oncology
Subjects:
chromatin bridges
abscission checkpoint
midbody
cytokinesis
atm
chk2
mrn
incenp
cpc
Online Access:http://dx.doi.org/10.1080/23723556.2021.1877999

Internet

http://dx.doi.org/10.1080/23723556.2021.1877999

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