Gut microbiota of old mice worsens neurological outcome after brain ischemia via increased valeric acid and IL-17 in the blood

Abstract Background Aging is a significant risk factor for ischemic stroke and worsens its outcome. However, the mechanisms for this worsened neurological outcome with aging are not clearly defined. Results Old C57BL/6J male mice (18 to 20 months old) had a poorer neurological outcome and more sever...

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Bibliographic Details
Main Authors: Xianzhang Zeng, Jun Li, Weiran Shan, Zhongmeng Lai, Zhiyi Zuo
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Microbiome
Subjects:
Online Access:https://doi.org/10.1186/s40168-023-01648-1