Tetrahydrocurcumin Add‐On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury

Tetrahydrocurcumin Add‐On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury

Abstract Tetrahydrocurcumin (THC), a principal metabolite of curcumin, was tested in a rat model of type 2 diabetes mellitus. THC was administered via daily oral gavage with the lipid carrier polyenylphosphatidylcholine (PPC) as add‐on therapy to losartan (angiotensin receptor blocker) to examine ef...

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Bibliographic Details
Main Authors: Mahyar Khazaeli, Ane C. F. Nunes, Yitong Zhao, Mahziar Khazaali, John Prudente, Nosratola D. Vaziri, Bhupinder Singh, Wei Ling Lau
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Pharmacology Research & Perspectives
Subjects:
animal models
chronic kidney diseases
diabetic nephropathy
losartan
proteinuria
tetrahydrocurcumin
Online Access:https://doi.org/10.1002/prp2.1079

Internet

https://doi.org/10.1002/prp2.1079

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