Pterostilbene attenuates heart failure by inhibiting myocardial ferroptosis through SIRT1/GSK-3β/GPX4 signaling pathway

Pterostilbene attenuates heart failure by inhibiting myocardial ferroptosis through SIRT1/GSK-3β/GPX4 signaling pathway

Sustained myocardial injury due to hypertension and diabetes mellitus leads to production of endogenous reactive oxygen species (ROS) and insufficient myocardial antioxidant capacity, increasing the risk of cardiomyocyte ferroptosis. Ferroptosis is a nonapoptotic form of cell death driven by unrestr...

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Bibliographic Details
Main Authors: Fan Zhang, Zhuanglin Zeng, Jiahui Zhang, Xuelian Li, Wenling Yang, Yumiao Wei, Xiaopeng Guo
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Pterostilbene
Ferroptosis
Heart failure
Cardiac remodeling
SIRT1/GSK-3β/GPX4 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024005930

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http://www.sciencedirect.com/science/article/pii/S2405844024005930

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