Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells

<p>Abstract</p> <p>Background</p> <p>Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria-derived activator of caspase (Smac/DIABLO) in enhancing the apoptosis-inducing potential of commonly used an...

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Bibliographic Details
Main Authors: Srivastava Rakesh K, Shankar Sharmila, Fandy Tamer E
Format: Article
Language:English
Published: BMC 2008-06-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/7/1/60