Indicators of increased ER stress and UPR in aged D2-mdx and human dystrophic skeletal muscles

Indicators of increased ER stress and UPR in aged D2-mdx and human dystrophic skeletal muscles

Duchenne muscular dystrophy (DMD) is a progressive muscle disease that results in muscle wasting, wheelchair dependence, and eventual death due to cardiac and respiratory complications. In addition to muscle fragility, dystrophin deficiency also results in multiple secondary dysfunctions, which may...

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Bibliographic Details
Main Authors: Swathy Krishna, Hannah R. Spaulding, James E. Koltes, John C. Quindry, Rudy J. Valentine, Joshua T. Selsby
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Physiology
Subjects:
DMD
mdx
dystrophin
unfolded protein response
transcription factor
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1152576/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1152576/full

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