Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage

Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage

Abstract Destruction of articular cartilage in osteoarthritis (OA) is initiated by depletion of the hyaluronan (HA)-aggrecan network, followed by degradation of the collagen fibrils. Previously, we reported the implications of HA-binding protein involved in HA depolymerization (HYBID), alias cell mi...

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Bibliographic Details
Main Authors: Jun Shiozawa, Susana de Vega, Chiho Yoshinaga, Xang Ji, Yoshifumi Negishi, Masahiro Momoeda, Tomomi Nakamura, Hiroyuki Yoshida, Haruka Kaneko, Muneaki Ishijima, Yasunori Okada
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22230-z

Internet

https://doi.org/10.1038/s41598-022-22230-z

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