Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation

Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation

B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dextran sodium sulfate (DSS)- or trinitrobenzenesulfonic acid...

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Bibliographic Details
Main Authors: Lisa Scandiuzzi, Kaya Ghosh, Kimberly A. Hofmeyer, Yael M. Abadi, Eszter Lázár-Molnár, Elaine Y. Lin, Qiang Liu, Hyungjun Jeon, Steven C. Almo, Lieping Chen, Stanley G. Nathenson, Xingxing Zang
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714000370

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http://www.sciencedirect.com/science/article/pii/S2211124714000370

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