Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function

Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function

IL-2 inducible T cell kinase (ITK) is critical in T helper subset differentiation and its inhibition has been suggested for the treatment of T cell-mediated inflammatory diseases. T follicular helper (Tfh), Th17 and regulatory T cells (Treg) also play important roles in the development of rheumatoid...

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Bibliographic Details
Main Authors: Ye Chen, Rongzhen Liang, Xiaoyi Shi, Rong Shen, Liu Liu, Yan Liu, Youqiu Xue, Xinghua Guo, Junlong Dang, Donglan Zeng, Feng Huang, Jianbo Sun, Jingwen Zhang, Julie Wang, Nancy Olsen, Avery August, Weishan Huang, Yunfeng Pan, Song Guo Zheng
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
ITK
Collagen-Induced Arthritis
RA
Treg/Th17
Tfh
Foxo1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016840

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http://www.sciencedirect.com/science/article/pii/S0753332223016840

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